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Cook, Paul
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Item TypeName
Concept Transaminases
Concept Ammonia
Concept Ammonium Sulfate
Concept Adenosine Triphosphate
Concept Adult
Concept Haplorhini
Concept Aged
Concept Alcaligenes
Concept Alcohol Dehydrogenase
Concept Alcohol Oxidoreductases
Concept Aldehyde Oxidoreductases
Concept Aldehyde Reductase
Concept Cadmium
Concept Acetyl Coenzyme A
Concept Acetylation
Concept Acrylates
Concept Carbohydrate Dehydrogenases
Concept Amides
Concept Amino Acid Oxidoreductases
Concept Amino Acid Sequence
Concept Acyl Coenzyme A
Concept Cyclic AMP
Concept Adenosine Diphosphate
Concept Adenosine Diphosphate Ribose
Concept Adenosine Monophosphate
Concept Blood Pressure
Concept Base Sequence
Concept Cattle
Concept Decarboxylation
Concept Biophysics
Concept Creatine Kinase
Concept Cyclodextrins
Concept Coenzyme A
Concept Cold Temperature
Concept Enterobacteriaceae
Concept Dose-Response Relationship, Drug
Concept Drosophila melanogaster
Concept Fibrinolysin
Concept Escherichia coli
Concept Hexokinase
Concept Guanosine Triphosphate
Concept Guinea Pigs
Concept Haemophilus influenzae
Concept Horses
Concept Humans
Concept Glucosephosphate Dehydrogenase
Concept Liver
Concept Oxo-Acid-Lyases
Concept Glucose-6-Phosphate Isomerase
Concept Glutamate Dehydrogenase
Concept Glutamates
Concept Glutamine
Concept Glutathione
Concept Glycerolphosphate Dehydrogenase
Concept Lysine
Concept Glycosylation
Concept L-Lactate Dehydrogenase
Concept Malate Dehydrogenase
Concept Inosine Triphosphate
Concept Fabaceae
Concept Niacinamide
Concept Muscles
Concept Nitrobenzenes
Concept Nitrobenzoates
Concept Nitrogen Isotopes
Concept Intestinal Mucosa
Concept Myocardium
Concept NAD
Concept NADP
Concept Naphthols
Concept Nucleotides
Concept Isocitrate Dehydrogenase
Concept Isoelectric Point
Concept Isomerism
Concept Nursing Staff
Concept Job Satisfaction
Concept Plants
Concept Plants, Medicinal
Concept Plasminogen
Concept Poly Adenosine Diphosphate Ribose
Concept Poly(ADP-ribose) Polymerases
Concept Middle Aged
Concept Phenylalanine
Concept Mitochondria
Concept Phosphates
Concept Phosphatidylinositols
Concept Phosphoadenosine Phosphosulfate
Concept Phosphocreatine
Concept Phosphofructokinase-1
Concept Phosphogluconate Dehydrogenase
Concept Potassium
Concept Molecular Sequence Data
Concept Phosphoric Monoester Hydrolases
Concept Phosphopeptides
Concept Phosphoric Acids
Concept Phosphorus Isotopes
Concept Phosphorus Radioisotopes
Concept Phosphorylation
Concept Phosphotransferases
Concept Motivation
Concept Phylogeny
Concept Precipitin Tests
Concept Pregnancy
Concept Pichia
Concept Piperidones
Concept Saccharomyces cerevisiae
Concept Saccharopine Dehydrogenases
Concept Salaries and Fringe Benefits
Concept Regression Analysis
Concept Salmonella typhimurium
Concept Patient Education as Topic
Concept L-Serine Dehydratase
Concept Peptide Fragments
Concept Peptides
Concept Risk Factors
Concept Sheep
Concept Periodicals as Topic
Concept Thymus Gland
Concept Swine
Concept Pyridoxal
Concept Pyridoxal Phosphate
Concept Pyridoxamine
Concept Diphosphates
Concept Rabbits
Concept Temperature
Concept Program Evaluation
Concept Thiadiazoles
Concept Nursing Evaluation Research
Concept Nursing Methodology Research
Concept 2,6-Dichloroindophenol
Concept HIV Infections
Concept Blotting, Western
Concept Restriction Mapping
Concept Drug Design
Concept Stereoisomerism
Concept Structure-Activity Relationship
Concept Students, Nursing
Concept Sugar Alcohol Dehydrogenases
Concept Sugar Phosphates
Concept Sulfonamides
Concept Point Mutation
Concept Arabidopsis
Concept Pseudomonas putida
Concept Protein Structure, Secondary
Concept Protein Structure, Tertiary
Concept Patient Satisfaction
Concept Vitamin K
Concept Risk Assessment
Concept Mutagenesis, Site-Directed
Concept Frail Elderly
Concept Open Reading Frames
Concept Glutamic Acid
Concept Acrylamide
Concept Mutation, Missense
Concept Hyphomicrobium
Concept Protein Renaturation
Concept Phenol
Concept Succinic Acid
Concept Sodium Azide
Concept Hydroxylamine
Concept Amino Acid Substitution
Concept Probability
Concept Dihydrouracil Dehydrogenase (NADP)
Concept Proline
Concept Propionibacterium
Concept Nurse's Role
Concept Drug Resistance, Bacterial
Concept Phosphofructokinases
Concept Protein Denaturation
Concept Protein Kinases
Concept Phosphofructokinase-2
Concept Protons
Concept Pseudomonas
Concept Carboxypeptidase B2
Concept Pterins
Concept Electron-Transferring Flavoproteins
Concept 2-Aminoadipate Transaminase
Concept Mice
Concept Rats
Concept Sodium
Concept Spectrometry, Fluorescence
Concept Triose-Phosphate Isomerase
Concept Tryptophan Synthase
Concept Uracil
Concept Comorbidity
Concept Logistic Models
Concept Mutagenesis, Insertional
Concept alpha-Cyclodextrins
Concept Intracellular Signaling Peptides and Proteins
Concept Total Quality Management
Concept Phosphotransferases (Alcohol Group Acceptor)
Concept Cyclic AMP-Dependent Protein Kinases
Concept DNA Primers
Concept Alanine Dehydrogenase
Concept Mitogen-Activated Protein Kinases
Concept Oxaloacetic Acid
Concept Organic Chemistry Phenomena
Concept Young Adult
Concept Arginine
Concept Asparagine
Concept Aspartic Acid
Concept Chickens
Concept Dimethylformamide
Concept Dipeptidases
Concept Dithionitrobenzoic Acid
Concept Flavins
Concept Fluorescence
Concept Fluorescence Polarization
Concept Fluorometry
Concept Formate Dehydrogenases
Concept Fructose-Bisphosphate Aldolase
Concept Indoles
Concept Methionine
Concept Oligopeptides
Concept Oncology Nursing
Concept Osmosis
Concept Oxaloacetates
Concept Oxygen Isotopes
Concept 4-Aminobenzoic Acid
Academic Article Time-resolved fluorescence of O-acetylserine sulfhydrylase.
Academic Article Glutamate 325 is a general acid-base catalyst in the reaction catalyzed by fructose-2,6-bisphosphatase.
Academic Article Pyridoxal 5'-phosphate-dependent alpha,beta-elimination reactions: mechanism of O-acetylserine sulfhydrylase.
Academic Article Expression of transglutaminase substrate activity on Candida albicans germ tubes through a coiled, disulfide-bonded N-terminal domain of Hwp1 requires C-terminal glycosylphosphatidylinositol modification.
Academic Article Purification and properties of beta-alanine synthase from calf liver.
Academic Article Optimum activity of the phosphofructokinase from Ascaris suum requires more than one metal ion.
Academic Article Overall kinetic mechanism of saccharopine dehydrogenase from Saccharomyces cerevisiae.
Academic Article Role of the S128, H186, and N187 triad in substrate binding and decarboxylation in the sheep liver 6-phosphogluconate dehydrogenase reaction.
Academic Article Structure, mechanism, and conformational dynamics of O-acetylserine sulfhydrylase from Salmonella typhimurium: comparison of A and B isozymes.
Academic Article Effect of mutation of lysine-120, located at the entry to the active site of O-acetylserine sulfhydrylase-A from Salmonella typhimurium.
Academic Article Role of Histidine-152 in cofactor orientation in the PLP-dependent O-acetylserine sulfhydrylase reaction.
Academic Article Examination of intrinsic sulfonamide resistance in Bacillus anthracis: a novel assay for dihydropteroate synthase.
Academic Article Evaluation of a career ladder program in an ambulatory care environment.
Academic Article Glutamates 78 and 122 in the active site of saccharopine dehydrogenase contribute to reactant binding and modulate the basicity of the acid-base catalysts.
Academic Article The multifaceted pyridoxal 5'-phosphate-dependent O-acetylserine sulfhydrylase.
Academic Article Evidence in support of lysine 77 and histidine 96 as acid-base catalytic residues in saccharopine dehydrogenase from Saccharomyces cerevisiae.
Academic Article pH dependence of the absorbance and 31P NMR spectra of O-acetylserine sulfhydrylase in the absence and presence of O-acetyl-L-serine.
Academic Article pH dependence of the kinetic parameters for the pyrophosphate-dependent phosphofructokinase reaction supports a proton-shuttle mechanism.
Academic Article Substrate activation by malate induced by oxalate in the Ascaris suum NAD-malic enzyme reaction.
Academic Article Inactivation of pyrophosphate-dependent phosphofructokinase from Propionibacterium freudenreichii by pyridoxal 5'-phosphate. Determination of the pH dependence of enzyme-reactant dissociation constants from protection against inactivation.
Academic Article Kinetic mechanism of pyrophosphate-dependent phosphofructokinase from Propionibacterium freudenreichii.
Academic Article Kinetic studies to determine the mechanism of regulation of bovine liver glutamate dehydrogenase by nucleotide effectors.
Academic Article Acid-base catalytic mechanism and pH dependence of fructose 2,6-bisphosphate activation of the Ascaris suum phosphofructokinase.
Academic Article Kinetic isotope effects as a probe of the beta-elimination reaction catalyzed by O-acetylserine sulfhydrylase.
Academic Article Lysine 183 is the general base in the 6-phosphogluconate dehydrogenase-catalyzed reaction.
Academic Article Substitution of pyridoxal 5'-phosphate in D-serine dehydratase from Escherichia coli by cofactor analogues provides information on cofactor binding and catalysis.
Academic Article Initial velocity, spectral, and pH studies of the serine-glyoxylate aminotransferase from Hyphomicrobiuim methylovorum.
Academic Article Crystal structure of the malic enzyme from Ascaris suum complexed with nicotinamide adenine dinucleotide at 2.3 A resolution.
Academic Article Alpha,beta-elimination reaction of O-acetylserine sulfhydrylase. Is the pyridine ring required?
Academic Article Role of methionine-13 in the catalytic mechanism of 6-phosphogluconate dehydrogenase from sheep liver.
Academic Article (31)P NMR studies of O-acetylserine sulfhydrylase-B from Salmonella typhimurium.
Academic Article Identification of the structural determinants for the stability of substrate and aminoacrylate external Schiff bases in O-acetylserine sulfhydrylase-A.
Academic Article Mechanism of the aromatic aminotransferase encoded by the Aro8 gene from Saccharomyces cerevisiae.
Academic Article Fructose 2,6-bisphosphate and AMP increase the affinity of the Ascaris suum phosphofructokinase for fructose 6-phosphate in a process separate from the relief of ATP inhibition.
Academic Article Kinetic studies on the activation of pyrophosphate-dependent phosphofructokinase from mung bean by fructose 2,6-bisphosphate and related compounds.
Academic Article Adenosine cyclic 3',5'-monophosphate dependent protein kinase: kinetic mechanism for the bovine skeletal muscle catalytic subunit.
Academic Article Solvent isotope effects on the reaction catalyzed by yeast hexokinase.
Academic Article pH studies toward the elucidation of the auxiliary catalyst for pig heart aspartate aminotransferase.
Academic Article Kinetic mechanism and location of rate-determining steps for aspartase from Hafnia alvei.
Academic Article Kinetic mechanism in the direction of oxidative decarboxylation for NAD-malic enzyme from Ascaris suum.
Academic Article Determination of dissociation constants for enzyme-reactant complexes for NAD-malic enzyme by modulation of the thiol inactivation rate.
Academic Article Use of isotope effects and pH studies to determine the chemical mechanism of Bacillus subtilis L-alanine dehydrogenase.
Academic Article Metal ion activator effects on intrinsic isotope effects for hydride transfer from decarboxylation in the reaction catalyzed by the NAD-malic enzyme from Ascaris suum.
Academic Article Substitution of pyridoxal 5'-phosphate in the O-acetylserine sulfhydrylase from Salmonella typhimurium by cofactor analogs provides a test of the mechanism proposed for formation of the alpha-aminoacrylate intermediate.
Academic Article A change in the internal aldimine lysine (K42) in O-acetylserine sulfhydrylase to alanine indicates its importance in transimination and as a general base catalyst.
Academic Article Cloning, expression, purification, and characterization of the 6-phosphogluconate dehydrogenase from sheep liver.
Academic Article Cysteine 42 is important for maintaining an integral active site for O-acetylserine sulfhydrylase resulting in the stabilization of the alpha-aminoacrylate intermediate.
Academic Article Oxidative decarboxylation of 6-phosphogluconate by 6-phosphogluconate dehydrogenase proceeds by a stepwise mechanism with NADP and APADP as oxidants.
Academic Article Expression and stereochemical and isotope effect studies of active 4-oxalocrotonate decarboxylase.
Academic Article O-acetylserine sulfhydrylase.
Academic Article Stabilization and characterization of histidine-tagged homocitrate synthase from Saccharomyces cerevisiae.
Academic Article Dihydropyrimidine dehydrogenase: a flavoprotein with four iron-sulfur clusters.
Academic Article Multiple isotope effects with alternative dinucleotide substrates as a probe of the malic enzyme reaction.
Academic Article Reaction of serine-glyoxylate aminotransferase with the alternative substrate ketomalonate indicates rate-limiting protonation of a quinonoid intermediate.
Academic Article Importance in catalysis of the 6-phosphate-binding site of 6-phosphogluconate in sheep liver 6-phosphogluconate dehydrogenase.
Academic Article Roles of histidines 154 and 189 and aspartate 139 in the active site of serine acetyltransferase from Haemophilus influenzae.
Academic Article Evidence for a catalytic dyad in the active site of homocitrate synthase from Saccharomyces cerevisiae.
Academic Article Molecular basis for the isozymes of bovine glucose-6-phosphate isomerase.
Academic Article Effects of osmolytes on the SLN1-YPD1-SSK1 phosphorelay system from Saccharomyces cerevisiae.
Academic Article Supporting role of lysine 13 and glutamate 16 in the acid-base mechanism of saccharopine dehydrogenase from Saccharomyces cerevisiae.
Academic Article Lanthanide pyrophosphates as substrates for the pyrophosphate-dependent phosphofructokinases from Propionibacterium freudenreichii and Phaseolus aureus: evidence for a second metal ion required for reaction.
Academic Article Product binding to the alpha-carboxyl subsite results in a conformational change at the active site of O-acetylserine sulfhydrylase-A: evidence from fluorescence spectroscopy.
Academic Article pH dependence of the kinetic mechanism of the adenosine 3',5'-monophosphate dependent protein kinase catalytic subunit in the direction of magnesium adenosine 5'-diphosphate phosphorylation.
Academic Article Kinetic and chemical mechanisms of the sheep liver 6-phosphogluconate dehydrogenase.
Academic Article Three-dimensional structure of O-acetylserine sulfhydrylase from Salmonella typhimurium.
Academic Article Glutamate 190 is a general acid catalyst in the 6-phosphogluconate-dehydrogenase-catalyzed reaction.
Academic Article Multiple isotope effects as a probe of proton and hydride transfer in the 6-phosphogluconate dehydrogenase reaction.
Academic Article Reaction mechanism of fructose-2,6-bisphosphatase. A mutation of nucleophilic catalyst, histidine 256, induces an alteration in the reaction pathway.
Academic Article Crystal structure of the H256A mutant of rat testis fructose-6-phosphate,2-kinase/fructose-2,6-bisphosphatase. Fructose 6-phosphate in the active site leads to mechanisms for both mutant and wild type bisphosphatase activities.
Academic Article Lysine 199 is the general acid in the NAD-malic enzyme reaction.
Academic Article Identification of an allosteric anion-binding site on O-acetylserine sulfhydrylase: structure of the enzyme with chloride bound.
Academic Article Detection of intermediates in reactions catalyzed by PLP-dependent enzymes: O-acetylserine sulfhydrylase and serine-glyoxalate aminotransferase.
Academic Article Characterization of the S272A,D site-directed mutations of O-acetylserine sulfhydrylase: involvement of the pyridine ring in the alpha,beta-elimination reaction.
Academic Article Interaction of serine acetyltransferase with O-acetylserine sulfhydrylase active site: evidence from fluorescence spectroscopy.
Academic Article The alpha-aminoadipate pathway for lysine biosynthesis in fungi.
Academic Article The 2'-phosphate of NADP is responsible for proper orientation of the nicotinamide ring in the oxidative decarboxylation reaction catalyzed by sheep liver 6-phosphogluconate dehydrogenase.
Academic Article Proper orientation of the nicotinamide ring of NADP is important for the precatalytic conformational change in the 6-phosphogluconate dehydrogenase reaction.
Academic Article Role of residues in the adenosine binding site of NAD of the Ascaris suum malic enzyme.
Academic Article A novel, species-specific class of uncompetitive inhibitors of gamma-glutamyl transpeptidase.
Academic Article Detection of a gem-diamine and a stable quinonoid intermediate in the reaction catalyzed by serine-glyoxylate aminotransferase from Hyphomicrobium methylovorum.
Academic Article para-Nitrophenyl sulfate activation of human sulfotransferase 1A1 is consistent with intercepting the E[middle dot]PAP complex and reformation of E[middle dot]PAPS.
Academic Article (31)P NMR spectroscopy senses the microenvironment of the 5'-phosphate group of enzyme-bound pyridoxal 5'-phosphate.
Academic Article Structure of 6-diazo-5-oxo-norleucine-bound human gamma-glutamyl transpeptidase 1, a novel mechanism of inactivation.
Academic Article Diethylpyrocarbonate inactivation of NAD-malic enzyme from Ascaris suum.
Academic Article Resolution of pyridoxal 5'-phosphate from O-acetylserine sulfhydrylase from Salmonella typhimurium and reconstitution of apoenzyme with cofactor and cofactor analogues as a probe of the cofactor binding site.
Academic Article Identification and spectral characterization of the external aldimine of the O-acetylserine sulfhydrylase reaction.
Academic Article Acid-base chemical mechanism of O-acetylserine sulfhydrylases-A and -B from pH studies.
Academic Article A pH-dependent allosteric transition in Ascaris suum phosphofructokinase distinct from that observed with fructose 2,6-bisphosphate.
Academic Article The 2'-phosphate of NADP is critical for optimum productive binding to 6-phosphogluconate dehydrogenase from Candida utilis.
Academic Article Pre-steady-state kinetics reveal a slow isomerization of the enzyme-NAD complex in the NAD-malic enzyme reaction.
Academic Article Overall kinetic mechanism of 6-phosphogluconate dehydrogenase from Candida utilis.
Academic Article Chemical mechanism of 6-phosphogluconate dehydrogenase from Candida utilis from pH studies.
Academic Article Kinetic mechanisms of the A and B isozymes of O-acetylserine sulfhydrylase from Salmonella typhimurium LT-2 using the natural and alternative reactants.
Academic Article Chemical mechanism of the fructose-6-phosphate,2-kinase reaction from the pH dependence of kinetic parameters of site-directed mutants of active site basic residues.
Grant STRUCTURE AND MECHANISM OF NAD-MALIC ENZYME
Grant STRUCTURE/MECHANISM OF 6-PHOSPHOGLUCONATE DEHYDROGENASE
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  • Transaminase
  • Isomerizing